Guide to Double Filtration Plasmapheresis Treatment
This advanced therapeutic procedure is primarily used for the selective removal of pathological substances from the plasma while preserving essential blood components. Below, you will find detailed information on protocols, indications, safety, side effects, timing, dose intervals, and the benefits of this treatment.
What is Double Filtration Plasmapheresis (DFPP)?
Double Filtration Plasmapheresis (DFPP) is a therapeutic apheresis technique that employs two consecutive filtration steps to selectively separate and remove plasma components. This procedure is designed to eliminate harmful substances from the blood, such as autoimmune factors, antibodies, and lipoproteins, while allowing vital components like proteins and cells to remain in circulation.
Pre-Consultation
A thorough assessment of the patient's medical history, current health conditions, and potential contraindications.
Blood Access
Catheter insertion or venous access is established to facilitate blood draw.
Initial Plasma Separation
Blood is drawn and passed through a primary filtration device that separates plasma from blood cells.
Second Filtration
The separated plasma is then passed through a secondary filter designed to target and remove specific pathological substances.
Reinfusion
The remaining blood components (red blood cells, platelets) are reinfused back into the patient.
Monitoring
Continuous observation of the patient’s vitals and overall status during and after the procedure.
DFPP may be indicated for various medical conditions, including but not limited to:
- Autoimmune diseases (e.g., lupus, rheumatoid arthritis)
- Hyperlipidemia (high lipid levels in blood)
- Neurological disorders (e.g., Guillain-Barré syndrome, Myasthenia gravis)
- Renal diseases (e.g., anti-GBM disease)
- Hemolytic anemia
- Sepsis and severe infections
- Conditions with elevated toxic metabolites
- Chronic fatigue syndrome
Safety
DFPP is generally considered safe when performed by trained healthcare professionals in a controlled clinical setting. Safety measures include:
Comprehensive patient evaluation to identify contraindications (e.g., bleeding disorders, severe hypertension)
Use of sterile and approved medical equipment
Constant monitoring of the patient’s vital signs and comfort level during the procedure
Side Effects
While DFPP is usually well-tolerated, some patients may experience:
- Temporary changes in blood pressure
- Mild dizziness or lightheadedness
- Fatigue
- Skin rash (rarely)
- Minor discomfort at the access site
Most side effects are transient and resolve quickly. Patients should communicate any unusual sensations or reactions to the healthcare provider immediately.
Timing and Dose Intervals
Recommended Frequency
- Initial Treatment - A series of sessions may be required, typically involving 3-5 treatments over a few weeks.
- Maintenance - - Depending on individual health needs, maintenance treatments can be scheduled every 1-3 months after the initial series.
Duration of Each Session
- Each DFPP session lasts approximately 2-4 hours, including preparation, procedures, and monitoring.
Benefits of Product DFPP Treatment
DFPP offers a variety of potential benefits, including:
01.
Selective Removal of Pathogens
Targets harmful antibodies and immune complexes without discarding essential blood components.
02.
Immune Modulation
Can help in rebalancing the immune system, potentially improving symptoms in autoimmune conditions.
03.
Improved Quality of Life
Many patients report symptomatic relief and enhanced overall well-being post-treatment.
04.
Lowered Lipid Levels
Effective in reducing high cholesterol and triglyceride levels in certain patients.
05.
Rapid Therapeutic Effects
Sometimes provides quicker symptom relief than traditional medications.